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Among n-3 PUFAs, DHA has demonstrated significant histological improvement in pediatric NAFLD, with Nobili and colleagues (Nobili et al., 2014) reporting reduced NAFLD Activity Score, steatosis, and ballooning after 18 months of supplementation, accompanied by decreased hepatic progenitor cell activation and pro-inflammatory macrophages through GPR120-mediated NF-B inhibition, with significant reductions in serum TNF-, IL-6, and IL-1

This real-world data is reassuring and suggests that any negative effect, if present, is not common

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